Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alias |
gptkb:ASF
ASF/SF2 SF2 |
| gptkbp:associatedWith |
gptkb:cancer
|
| gptkbp:domain |
gptkb:RS_domain
RNA recognition motif |
| gptkbp:Entrez_Gene_ID |
6426
ENSG00000136450 |
| gptkbp:expressedIn |
various tissues
|
| gptkbp:fullName |
Serine/arginine-rich splicing factor 1
|
| gptkbp:function |
genome stability
translation regulation regulation of alternative splicing mRNA export splicing factor |
| gptkbp:geneType |
protein-coding
|
| gptkbp:HGNC_ID |
10772
|
| https://www.w3.org/2000/01/rdf-schema#label |
SRSF1
|
| gptkbp:interactsWith |
gptkb:RNA_polymerase_II
other SR proteins |
| gptkbp:locatedOnChromosome |
17
|
| gptkbp:location |
17q22-q23
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
mouse Srsf1
rat Srsf1 zebrafish srsf1 |
| gptkbp:overexpressedIn |
oncogenic transformation
|
| gptkbp:phosphorylates |
regulates activity
|
| gptkbp:postTranslationalModification |
phosphorylation
methylation acetylation |
| gptkbp:proteinFamily |
SR protein family
|
| gptkbp:regulates |
apoptosis
cell proliferation cell cycle mRNA stability nonsense-mediated mRNA decay translation initiation alternative splicing of multiple genes exon inclusion/exclusion splicing enhancer activity splicing silencer activity |
| gptkbp:relatedTo |
mRNA processing
pre-mRNA splicing |
| gptkbp:requires |
embryonic development
cell viability |
| gptkbp:subcellularLocation |
gptkb:nucleus
gptkb:cytoplasm nuclear speckles |
| gptkbp:UniProtID |
Q07955
|
| gptkbp:bfsParent |
gptkb:RRM_domain
gptkb:hnRNPA1 gptkb:HNRNPA1 |
| gptkbp:bfsLayer |
7
|