Heterogeneous nuclear ribonucleoprotein A1
GPTKB entity
Statements (47)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:protein
|
gptkbp:alternativeName |
gptkb:hnRNP_A1
heterogeneous nuclear ribonucleoprotein core protein A1 |
gptkbp:associatedWith |
gptkb:multisystem_proteinopathy
amyotrophic lateral sclerosis |
gptkbp:biologicalProcess |
regulation of gene expression
alternative splicing mRNA export from nucleus |
gptkbp:Entrez_Gene_ID |
ENSP00000354825
|
gptkbp:expressedIn |
many tissues
|
gptkbp:foundIn |
gptkb:Homo_sapiens
|
gptkbp:function |
RNA binding
mRNA transport pre-mRNA processing |
gptkbp:gene |
gptkb:HNRNPA1
|
gptkbp:hasIsoform |
hnRNP A1A
hnRNP A1B |
https://www.w3.org/2000/01/rdf-schema#label |
Heterogeneous nuclear ribonucleoprotein A1
|
gptkbp:interactsWith |
gptkb:SRSF1
gptkb:HNRNPA2B1 |
gptkbp:involves |
neurodegenerative diseases
DNA damage response viral replication HIV-1 RNA metabolism stress granule formation |
gptkbp:length |
372 amino acids
|
gptkbp:locatedOnChromosome |
12q13.13
|
gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
gptkbp:molecularWeight |
~34 kDa
|
gptkbp:OMIM |
164017
|
gptkbp:PDB |
gptkb:1HA1
|
gptkbp:postTranslationalModification |
phosphorylation
methylation |
gptkbp:RefSeq |
NP_002127.1
|
gptkbp:regulates |
apoptosis
cell proliferation translator telomere maintenance RNA stability |
gptkbp:structure |
contains two RNA recognition motifs (RRMs)
glycine-rich C-terminal domain |
gptkbp:subcellularLocation |
shuttles between nucleus and cytoplasm
|
gptkbp:UniProtID |
gptkb:P09651
|
gptkbp:bfsParent |
gptkb:hnRNPA1
gptkb:HNRNPA1 |
gptkbp:bfsLayer |
7
|