Heterogeneous nuclear ribonucleoprotein A1

GPTKB entity

Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:hnRNP_A1
heterogeneous nuclear ribonucleoprotein core protein A1
gptkbp:associatedWith gptkb:multisystem_proteinopathy
amyotrophic lateral sclerosis
gptkbp:biologicalProcess regulation of gene expression
alternative splicing
mRNA export from nucleus
gptkbp:Entrez_Gene_ID ENSP00000354825
gptkbp:expressedIn many tissues
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function RNA binding
mRNA transport
pre-mRNA processing
gptkbp:gene gptkb:HNRNPA1
gptkbp:hasIsoform hnRNP A1A
hnRNP A1B
https://www.w3.org/2000/01/rdf-schema#label Heterogeneous nuclear ribonucleoprotein A1
gptkbp:interactsWith gptkb:SRSF1
gptkb:HNRNPA2B1
gptkbp:involves neurodegenerative diseases
DNA damage response
viral replication
HIV-1 RNA metabolism
stress granule formation
gptkbp:length 372 amino acids
gptkbp:locatedOnChromosome 12q13.13
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight ~34 kDa
gptkbp:OMIM 164017
gptkbp:PDB gptkb:1HA1
gptkbp:postTranslationalModification phosphorylation
methylation
gptkbp:RefSeq NP_002127.1
gptkbp:regulates apoptosis
cell proliferation
translator
telomere maintenance
RNA stability
gptkbp:structure contains two RNA recognition motifs (RRMs)
glycine-rich C-terminal domain
gptkbp:subcellularLocation shuttles between nucleus and cytoplasm
gptkbp:UniProtID gptkb:P09651
gptkbp:bfsParent gptkb:hnRNPA1
gptkb:HNRNPA1
gptkbp:bfsLayer 7