glycogen synthase kinase-3 alpha

URI: https://gptkb.org/entity/glycogen_synthase_kinase-3_alpha
GPTKB entity
Statements (45)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName GSK-3A
GSK3 alpha
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:diabetes_mellitus
bipolar disorder
gptkbp:discoveredBy 1990
gptkbp:Entrez_Gene_ID 2931
ENSG00000105723
gptkbp:enzymeCommissionNumber EC 2.7.11.26
gptkbp:expressedIn gptkb:skeletal_muscle
brain
liver
gptkbp:family protein kinase family
CMGC kinase group
gptkbp:function serine/threonine protein kinase
phosphorylation of glycogen synthase
gptkbp:gene gptkb:GSK3A
gptkbp:hasParalog gptkb:glycogen_synthase_kinase-3_beta
gptkbp:HGNC_ID 4617
https://www.w3.org/2000/01/rdf-schema#label glycogen synthase kinase-3 alpha
gptkbp:inhibitedBy gptkb:insulin
lithium
gptkbp:involves gptkb:Wnt_signaling_pathway
glycogen metabolism
insulin signaling pathway
gptkbp:locatedOnChromosome 19q13.2
gptkbp:molecularWeight 51 kDa
gptkbp:OMIM 606784
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Gsk3a
gptkbp:PDB gptkb:1Q4L
gptkbp:phosphorylates gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:beta-catenin
Ser21
Tyr279
gptkbp:RefSeq NM_019884
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:subunit homodimer
monomer
gptkbp:UniProtID gptkb:P49840
gptkbp:bfsParent gptkb:19q13.2_(GSK3A)
gptkbp:bfsLayer 7