|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:GAD
gptkb:GAD65
gptkb:GAD67
|
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gptkbp:associatedWith
|
epilepsy (when mutated)
type 1 diabetes (autoantigen)
|
|
gptkbp:autoantigen_in
|
gptkb:Stiff-person_syndrome
gptkb:Type_1_diabetes
|
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gptkbp:biologicalProcess
|
gptkb:GABA_biosynthetic_process
amino acid decarboxylase activity
|
|
gptkbp:catalyzes
|
decarboxylation of glutamate to GABA
|
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gptkbp:cellularComponent
|
gptkb:cytoplasm
|
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gptkbp:chromosome_location_(GAD1,_human)
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gptkb:chromosome_2q31
|
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gptkbp:chromosome_location_(GAD2,_human)
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gptkb:chromosome_10p11.23
|
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gptkbp:cofactor
|
gptkb:pyridoxal_phosphate
|
|
gptkbp:EC_number
|
4.1.1.15
|
|
gptkbp:expressedIn
|
gptkb:kidney
gptkb:testis
central nervous system
liver
pancreatic beta cells
|
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gptkbp:foundIn
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gptkb:Bacteria
animals
plants
|
|
gptkbp:gene
|
gptkb:GAD1
gptkb:GAD2
|
|
gptkbp:GO_term
|
gptkb:GO:0004351
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
glutamate decarboxylase
|
|
gptkbp:inhibitedBy
|
gptkb:3-mercaptopropionic_acid
allylglycine
|
|
gptkbp:involves
|
synaptic transmission
inhibitory signaling
neurotransmitter metabolism
|
|
gptkbp:OMIM_ID_(GAD1)
|
605363
|
|
gptkbp:OMIM_ID_(GAD2)
|
138275
|
|
gptkbp:optimum_pH
|
6.0
|
|
gptkbp:orthologInMouse
|
gptkb:Gad1
gptkb:Gad2
|
|
gptkbp:PDB_ID_(structure)
|
gptkb:1OHV
2OKJ
|
|
gptkbp:product
|
gptkb:gamma-aminobutyric_acid
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:L-glutamate
|
|
gptkbp:UniProt_ID_(GAD1)
|
gptkb:Q99259
|
|
gptkbp:UniProt_ID_(GAD2)
|
gptkb:Q9NZT2
|
|
gptkbp:bfsParent
|
gptkb:gamma-aminobutyric_acid
gptkb:glutamic_acid_decarboxylase
|
|
gptkbp:bfsLayer
|
6
|