glutamic acid decarboxylase

URI: https://gptkb.org/entity/glutamic_acid_decarboxylase
GPTKB entity
Statements (35)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:GAD
gptkb:GADase
gptkb:glutamate_decarboxylase
gptkbp:associatedWith epilepsy
schizophrenia
stiff-person syndrome
autoimmune encephalitis
gptkbp:autoantigen_in type 1 diabetes
gptkbp:catalyzes decarboxylation of glutamate to GABA
gptkbp:chromosome_location_(GAD1) gptkb:chromosome_2q31
gptkbp:chromosome_location_(GAD2) gptkb:chromosome_10p11.23
gptkbp:cofactor gptkb:pyridoxal_phosphate
gptkbp:discoveredBy 1950s
gptkbp:EC_number 4.1.1.15
gptkbp:expressedIn neurons
pancreatic beta cells
gptkbp:foundIn brain
pancreas
gptkbp:gene gptkb:GAD1
gptkb:GAD2
gptkbp:hasIsoform gptkb:GAD65
gptkb:GAD67
https://www.w3.org/2000/01/rdf-schema#label glutamic acid decarboxylase
gptkbp:inhibitedBy gptkb:3-mercaptopropionic_acid
gptkbp:involves GABAergic neurotransmission
gptkbp:molecularWeight ~65 kDa (GAD65)
~67 kDa (GAD67)
gptkbp:product gptkb:gamma-aminobutyric_acid
gptkbp:structure homodimer
gptkbp:substrate gptkb:L-glutamate
gptkbp:UniProt_ID_(GAD1) gptkb:Q99259
gptkbp:UniProt_ID_(GAD2) gptkb:Q9NZ42
gptkbp:bfsParent gptkb:GABA
gptkbp:bfsLayer 5