glutamic acid decarboxylase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:alternativeName	gptkb:GAD gptkb:GADase gptkb:glutamate_decarboxylase
gptkbp:associatedWith	epilepsy schizophrenia stiff-person syndrome autoimmune encephalitis
gptkbp:autoantigen_in	type 1 diabetes
gptkbp:catalyzes	decarboxylation of glutamate to GABA
gptkbp:chromosome_location_(GAD1)	gptkb:chromosome_2q31
gptkbp:chromosome_location_(GAD2)	gptkb:chromosome_10p11.23
gptkbp:cofactor	gptkb:pyridoxal_phosphate
gptkbp:discoveredBy	1950s
gptkbp:EC_number	4.1.1.15
gptkbp:expressedIn	gptkb:neurons pancreatic beta cells
gptkbp:foundIn	brain pancreas
gptkbp:gene	gptkb:GAD1 gptkb:GAD2
gptkbp:hasIsoform	gptkb:GAD65 gptkb:GAD67
gptkbp:inhibitedBy	gptkb:3-mercaptopropionic_acid
gptkbp:involves	GABAergic neurotransmission
gptkbp:molecularWeight	~65 kDa (GAD65) ~67 kDa (GAD67)
gptkbp:product	gptkb:gamma-aminobutyric_acid
gptkbp:structure	homodimer
gptkbp:substrate	gptkb:L-glutamate
gptkbp:UniProt_ID_(GAD1)	gptkb:Q99259
gptkbp:UniProt_ID_(GAD2)	gptkb:Q9NZ42
gptkbp:bfsParent	gptkb:GABA
gptkbp:bfsLayer	5
https://www.w3.org/2000/01/rdf-schema#label	glutamic acid decarboxylase