glucose-6-phosphate dehydrogenase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:activatedBy	gptkb:insulin high NADP+ levels
gptkbp:alternativeName	gptkb:G6PD gptkb:G6PDH gptkb:G6P_dehydrogenase
gptkbp:associatedWith	gptkb:anemia
gptkbp:biologicalProcess	cellular response to oxidative stress oxidoreductase activity NADPH regeneration
gptkbp:CASNumber	9001-40-5
gptkbp:catalyzes	oxidation of glucose-6-phosphate to 6-phosphoglucono-δ-lactone
gptkbp:cofactor	NADP+
gptkbp:deficiencyCauses	glucose-6-phosphate dehydrogenase deficiency
gptkbp:EC_number	1.1.1.49
gptkbp:gene	gptkb:G6PD
gptkbp:HGNC_ID	4057
gptkbp:inhibitedBy	palmitoyl-CoA dehydroepiandrosterone
gptkbp:locatedOnChromosome	gptkb:Xq28
gptkbp:location	gptkb:cytoplasm
gptkbp:OMIM	305900
gptkbp:organism	gptkb:Homo_sapiens gptkb:Bacteria
gptkbp:pathway	gptkb:pentose_phosphate_pathway
gptkbp:PDB	2BH9
gptkbp:product	gptkb:6-phosphoglucono-δ-lactone NADPH
gptkbp:requires	red blood cell protection from oxidative damage
gptkbp:structure	homodimer homotetramer
gptkbp:substrate	gptkb:glucose-6-phosphate NADP+
gptkbp:UniProtID	P11413
gptkbp:bfsParent	gptkb:G6PD_deficiency gptkb:G6PD gptkb:G6PD_gene gptkb:pentose_phosphate_pathway gptkb:NP_000194
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	glucose-6-phosphate dehydrogenase