glucose-6-phosphate dehydrogenase

URI: https://gptkb.org/entity/glucose-6-phosphate_dehydrogenase
GPTKB entity
Statements (37)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activatedBy gptkb:insulin
high NADP+ levels
gptkbp:alternativeName gptkb:G6PD
gptkb:G6PDH
gptkb:G6P_dehydrogenase
gptkbp:associatedWith gptkb:anemia
gptkbp:biologicalProcess cellular response to oxidative stress
oxidoreductase activity
NADPH regeneration
gptkbp:CASNumber 9001-40-5
gptkbp:catalyzes oxidation of glucose-6-phosphate to 6-phosphoglucono-δ-lactone
gptkbp:cofactor NADP+
gptkbp:deficiencyCauses glucose-6-phosphate dehydrogenase deficiency
gptkbp:EC_number 1.1.1.49
gptkbp:gene gptkb:G6PD
gptkbp:HGNC_ID 4057
https://www.w3.org/2000/01/rdf-schema#label glucose-6-phosphate dehydrogenase
gptkbp:inhibitedBy palmitoyl-CoA
dehydroepiandrosterone
gptkbp:locatedOnChromosome gptkb:Xq28
gptkbp:location gptkb:cytoplasm
gptkbp:OMIM 305900
gptkbp:organism gptkb:Homo_sapiens
gptkb:Bacteria
gptkbp:pathway gptkb:pentose_phosphate_pathway
gptkbp:PDB 2BH9
gptkbp:product gptkb:6-phosphoglucono-δ-lactone
NADPH
gptkbp:requires red blood cell protection from oxidative damage
gptkbp:structure homodimer
homotetramer
gptkbp:substrate gptkb:glucose-6-phosphate
NADP+
gptkbp:UniProtID P11413
gptkbp:bfsParent gptkb:G6PD_deficiency
gptkbp:bfsLayer 6