pentose phosphate pathway

URI: https://gptkb.org/entity/pentose_phosphate_pathway

GPTKB entity

Predicate	Object
gptkbp:instanceOf	biological pathway
gptkbp:alsoKnownAs	gptkb:hexose_monophosphate_shunt gptkb:phosphogluconate_pathway
gptkbp:connectsTo	glucose metabolism glycolysis
gptkbp:deficiencyCauses	gptkb:anemia oxidative stress
gptkbp:discoveredBy	gptkb:Otto_Warburg
https://www.w3.org/2000/01/rdf-schema#label	pentose phosphate pathway
gptkbp:importantFor	antioxidant defense fatty acid synthesis nucleotide synthesis cholesterol synthesis
gptkbp:mainEnzyme	gptkb:glucose-6-phosphate_dehydrogenase gptkb:transketolase gptkb:6-phosphogluconate_dehydrogenase gptkb:transaldolase
gptkbp:mainFunction	generate NADPH produce ribose-5-phosphate provide intermediates for nucleotide synthesis
gptkbp:occurredIn	gptkb:cytoplasm
gptkbp:period	non-oxidative phase oxidative phase
gptkbp:presentIn	prokaryotes eukaryotes
gptkbp:product	CO2 NADPH glyceraldehyde-3-phosphate fructose-6-phosphate ribose-5-phosphate
gptkbp:regulates	inhibited by high NADPH stimulated by NADP+
gptkbp:substrate	gptkb:glucose-6-phosphate
gptkbp:bfsParent	gptkb:transketolase gptkb:NP_000445.1
gptkbp:bfsLayer	6