|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activity
|
gptkb:acyl_carrier_protein
gptkb:dehydratase
gptkb:enoyl_reductase
gptkb:ketoacyl_reductase
gptkb:ketoacyl_synthase
gptkb:thioesterase
malonyl/acetyl transferase
|
|
gptkbp:alternativeName
|
gptkb:FASN
gptkb:fatty_acid_synthase_complex
gptkb:FAS
fatty acid synthetase
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:catalyzes
|
fatty acid synthesis
|
|
gptkbp:EC_number
|
2.3.1.85
|
|
gptkbp:expressedIn
|
liver
adipose tissue
mammary gland
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
fungi
|
|
gptkbp:gene
|
gptkb:FASN
|
|
gptkbp:GO_term
|
gptkb:GO:0004312
|
|
gptkbp:homologous_to
|
bacterial fatty acid synthase
yeast fatty acid synthase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
fatty acid synthase
|
|
gptkbp:inhibitedBy
|
gptkb:C75
gptkb:cerulenin
gptkb:orlistat
|
|
gptkbp:locatedOnChromosome
|
17q25.3 (human)
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~500 kDa
|
|
gptkbp:pathway
|
fatty acid biosynthesis
lipogenesis
|
|
gptkbp:PDB
|
2VZ8
|
|
gptkbp:product
|
gptkb:palmitate
|
|
gptkbp:regulates
|
gptkb:insulin
gptkb:AMPK
gptkb:SREBP-1c
glucose
PUFA
|
|
gptkbp:significance
|
gptkb:type_2_diabetes
gptkb:metabolic_syndrome
obesity
|
|
gptkbp:structure
|
multienzyme complex
|
|
gptkbp:substrate
|
gptkb:malonyl-CoA
NADPH
acetyl-CoA
|
|
gptkbp:subunit
|
alpha subunit
beta subunit
|
|
gptkbp:UniProtID
|
gptkb:P49327
|
|
gptkbp:bfsParent
|
gptkb:FASN
gptkb:cerulenin
gptkb:malonyl-CoA
gptkb:palmitic_acid
gptkb:CHEBI:15765
gptkb:ChREBP
|
|
gptkbp:bfsLayer
|
7
|