|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:FAS
gptkb:FAS1
gptkb:FAS2
gptkb:OA-519
SDR27X1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:metabolic_syndrome
obesity
|
|
gptkbp:biologicalProcess
|
oxidoreductase activity
acyl-carrier-protein S-acetyltransferase activity
fatty acid biosynthetic process
lipid metabolic process
malonyl-CoA decarboxylase activity
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
|
|
gptkbp:encodes
|
gptkb:fatty_acid_synthase_enzyme
|
|
gptkbp:Entrez_Gene_ID
|
2194
ENSG00000169710
|
|
gptkbp:enzymeCommissionNumber
|
2.3.1.85
|
|
gptkbp:expressedIn
|
liver
adipose tissue
mammary gland
|
|
gptkbp:fullName
|
gptkb:fatty_acid_synthase
|
|
gptkbp:function
|
catalyzes de novo synthesis of fatty acids
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:3594
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FASN
|
|
gptkbp:locatedOnChromosome
|
17q25.3
|
|
gptkbp:mutationAssociatedWith
|
can cause metabolic disorders
|
|
gptkbp:OMIM
|
600212
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Fasn
|
|
gptkbp:pathway
|
lipid metabolism
fatty acid biosynthesis
|
|
gptkbp:PDB
|
2VZ8
3HHD
|
|
gptkbp:product
|
gptkb:fatty_acid_synthase
|
|
gptkbp:regulates
|
regulated by insulin
regulated by SREBP-1
upregulated in some cancers
|
|
gptkbp:target
|
gptkb:C75
gptkb:cerulenin
gptkb:orlistat
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P49327
|
|
gptkbp:bfsParent
|
gptkb:Fatty_Acid_Synthase
|
|
gptkbp:bfsLayer
|
6
|