Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:catalyzes |
formation of long-chain saturated fatty acids
|
| gptkbp:cofactor |
NADPH
|
| gptkbp:EC_number |
2.3.1.85
|
| gptkbp:foundIn |
animals
fungi plants |
| gptkbp:function |
fatty acid biosynthesis
|
| gptkbp:gene |
gptkb:FASN
|
| https://www.w3.org/2000/01/rdf-schema#label |
fatty acid synthase complex
|
| gptkbp:inhibitedBy |
gptkb:C75
gptkb:cerulenin gptkb:orlistat |
| gptkbp:location |
gptkb:cytoplasm
|
| gptkbp:molecularWeight |
~250-270 kDa (mammals)
|
| gptkbp:product |
gptkb:CoA
gptkb:palmitate CO2 |
| gptkbp:relatedTo |
obesity
cancer metabolism lipogenesis |
| gptkbp:structure |
multifunctional polypeptide
|
| gptkbp:substrate |
gptkb:malonyl-CoA
acetyl-CoA |
| gptkbp:subunit |
gptkb:acyl_carrier_protein
gptkb:dehydratase gptkb:enoyl_reductase gptkb:ketoacyl_reductase gptkb:ketoacyl_synthase gptkb:malonyl/acetyltransferase gptkb:thioesterase |
| gptkbp:bfsParent |
gptkb:Fatty_Acid_Synthase
|
| gptkbp:bfsLayer |
6
|