endothelial nitric oxide synthase

URI: https://gptkb.org/entity/endothelial_nitric_oxide_synthase
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activatedBy gptkb:insulin
gptkb:bradykinin
gptkb:acetylcholine
estrogen
shear stress
gptkbp:alsoKnownAs gptkb:eNOS
gptkbp:cofactor gptkb:FMN
gptkb:FAD
gptkb:tetrahydrobiopterin
NADPH
gptkbp:discoveredBy 1990s
gptkbp:EC_number 1.14.13.39
gptkbp:expressedIn gptkb:cardiac_myocytes
platelets
vascular endothelium
gptkbp:function synthesizes nitric oxide
gptkbp:gene NOS3
https://www.w3.org/2000/01/rdf-schema#label endothelial nitric oxide synthase
gptkbp:inhibitedBy gptkb:caveolin-1
gptkb:tobacco_smoke
gptkb:L-NAME
high cholesterol
oxidative stress
homocysteine
asymmetric dimethylarginine (ADMA)
gptkbp:locatedOnChromosome 7q36
gptkbp:location endothelial cells
gptkbp:molecularWeight ~135 kDa
gptkbp:mutationAssociatedWith gptkb:cardiovascular_disease
gptkb:diabetes_mellitus
hypertension
gptkbp:PDB 1M9M
gptkbp:phosphorylated_at Ser1177
Ser615
Ser633
Thr495
gptkbp:product nitric oxide
L-citrulline
gptkbp:regulates phosphorylation
calcium/calmodulin
gptkbp:role regulation of blood pressure
vasodilation
inhibition of platelet aggregation
prevention of atherosclerosis
gptkbp:structure homodimer
gptkbp:substrate gptkb:L-arginine
gptkbp:UniProtID P29474
gptkbp:bfsParent gptkb:Nitric_oxide_synthase
gptkb:eNOS
gptkbp:bfsLayer 7