Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:receptor_tyrosine_kinase
gptkb:protein |
| gptkbp:alternativeName |
gptkb:CD117
|
| gptkbp:discoveredBy |
Toshio Hirai
|
| gptkbp:discoveredIn |
1987
|
| gptkbp:encodedBy |
gptkb:KIT_gene
|
| gptkbp:expressedIn |
gptkb:melanocytes
gptkb:interstitial_cells_of_Cajal gptkb:germ_cells hematopoietic stem cells |
| gptkbp:function |
regulation of cell differentiation
regulation of cell proliferation regulation of cell survival cell signal transduction |
| https://www.w3.org/2000/01/rdf-schema#label |
c-Kit
|
| gptkbp:ligand |
gptkb:stem_cell_factor
|
| gptkbp:locatedOnChromosome |
4q12
|
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:mutationAssociatedWith |
gptkb:gastrointestinal_stromal_tumor
gptkb:mastocytosis gptkb:acute_myeloid_leukemia piebladism |
| gptkbp:phosphorylates |
tyrosine residues
|
| gptkbp:target |
gptkb:dasatinib
gptkb:imatinib gptkb:regorafenib gptkb:sunitinib |
| gptkbp:UniProtID |
P10721
|
| gptkbp:bfsParent |
gptkb:CHEMBL958
gptkb:SU5498 gptkb:Votrient |
| gptkbp:bfsLayer |
6
|