Philadelphia chromosome-positive acute lymphoblastic leukemia

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:disease gptkb:acute_lymphoblastic_leukemia_subtype
gptkbp:abbreviation	Ph+ ALL
gptkbp:firstDescribed	gptkb:Janet_Rowley 1973
gptkbp:hasDiagnosticMethod	gptkb:FISH cytogenetic analysis PCR for BCR-ABL1
gptkbp:hasFusionGene	BCR-ABL1
gptkbp:hasGeneticAlteration	gptkb:Philadelphia_chromosome
gptkbp:hasOrphanetID	ORPHA:99860
gptkbp:hasParentDisease	gptkb:leukemia
gptkbp:hasRelapseRisk	high
gptkbp:hasTargetedTherapy	tyrosine kinase inhibitors
gptkbp:hasTranslocation	t(9;22)(q34;q11)
gptkbp:ICD-10_code	gptkb:C91.0
gptkbp:incidence	2-5% of pediatric ALL cases 20-30% of adult ALL cases
gptkbp:OMIM	613065
gptkbp:prognosis	generally poorer than Ph-negative ALL
gptkbp:riskFactor	older age male gender
gptkbp:symptom	fever fatigue easy bruising frequent infections
gptkbp:treatment	gptkb:dasatinib gptkb:imatinib gptkb:allogeneic_stem_cell_transplantation chemotherapy tyrosine kinase inhibitors
gptkbp:bfsParent	gptkb:dasatinib gptkb:ponatinib gptkb:CHEMBL458
gptkbp:bfsLayer	8
http://www.w3.org/2000/01/rdf-schema#label	Philadelphia chromosome-positive acute lymphoblastic leukemia