Philadelphia chromosome-positive acute lymphoblastic leukemia

URI: https://gptkb.org/entity/Philadelphia_chromosome-positive_acute_lymphoblastic_leukemia
GPTKB entity
Statements (37)
Predicate Object
gptkbp:instanceOf gptkb:disease
acute lymphoblastic leukemia subtype
gptkbp:abbreviation Ph+ ALL
gptkbp:firstDescribed gptkb:Janet_Rowley
1973
gptkbp:hasDiagnosticMethod gptkb:FISH
cytogenetic analysis
PCR for BCR-ABL1
gptkbp:hasFusionGene BCR-ABL1
gptkbp:hasGeneticAlteration gptkb:Philadelphia_chromosome
gptkbp:hasOrphanetID ORPHA:99860
gptkbp:hasParentDisease leukemia
gptkbp:hasRelapseRisk high
gptkbp:hasTargetedTherapy tyrosine kinase inhibitors
gptkbp:hasTranslocation t(9;22)(q34;q11)
https://www.w3.org/2000/01/rdf-schema#label Philadelphia chromosome-positive acute lymphoblastic leukemia
gptkbp:ICD-10_code gptkb:C91.0
gptkbp:incidence 2-5% of pediatric ALL cases
20-30% of adult ALL cases
gptkbp:OMIM 613065
gptkbp:prognosis generally poorer than Ph-negative ALL
gptkbp:riskFactor older age
male gender
gptkbp:symptom fever
fatigue
easy bruising
frequent infections
gptkbp:treatment gptkb:dasatinib
gptkb:imatinib
gptkb:allogeneic_stem_cell_transplantation
chemotherapy
tyrosine kinase inhibitors
gptkbp:bfsParent gptkb:dasatinib
gptkb:ponatinib
gptkb:CHEMBL458
gptkb:AMN107
gptkbp:bfsLayer 7