|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:absorption
|
gptkb:small_intestine
|
|
gptkbp:approvedBy
|
omeprazole in 1988
|
|
gptkbp:ATCCode
|
gptkb:A02BC
|
|
gptkbp:bioavailability
|
varies by drug
|
|
gptkbp:category
|
gastrointestinal agent
acid suppressant
|
|
gptkbp:chemicalClass
|
substituted benzimidazoles
|
|
gptkbp:contraindication
|
known hypersensitivity
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:drugInteraction
|
gptkb:warfarin
gptkb:clopidogrel
gptkb:methotrexate
|
|
gptkbp:effect
|
reduce stomach acid production
|
|
gptkbp:eliminationHalfLife
|
1-2 hours
|
|
gptkbp:example
|
gptkb:omeprazole
gptkb:pantoprazole
gptkb:lansoprazole
gptkb:rabeprazole
gptkb:dexlansoprazole
esomeprazole
|
|
gptkbp:form
|
capsule
oral suspension
intravenous injection
delayed-release tablet
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
proton pump inhibitors
|
|
gptkbp:legalStatus
|
prescription
over-the-counter (some drugs)
|
|
gptkbp:mechanismOfAction
|
inhibit gastric H+/K+ ATPase
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
varies by drug
|
|
gptkbp:riskFactor
|
gptkb:pneumonia
chronic kidney disease
vitamin B12 deficiency
gastric cancer (long-term use, debated)
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nausea
diarrhea
abdominal pain
headache
hypomagnesemia
increased risk of Clostridioides difficile infection
osteoporosis-related fractures
|
|
gptkbp:usedFor
|
treatment of peptic ulcer disease
treatment of Zollinger-Ellison syndrome
treatment of gastroesophageal reflux disease
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
gptkb:omeprazole
|
|
gptkbp:bfsParent
|
gptkb:Helicobacter_pylori_infection
gptkb:Barrett's_esophagus
gptkb:Esophagitis
gptkb:Adderall
gptkb:gastroesophageal_reflux_disease
gptkb:peptic_ulcer
gptkb:Cushing_ulcer
gptkb:ketoconazole
gptkb:GERD
gptkb:Helicobacter_pylori
gptkb:H2_blocker
|
|
gptkbp:bfsLayer
|
6
|