Statements (61)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:alternativeName |
gptkb:CYP1A2
P450 1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 |
| gptkbp:catalyzes |
oxidation of xenobiotics
N-oxidation of heterocyclic amines O-dealkylation of phenacetin demethylation of caffeine hydroxylation of aromatic amines metabolism of R-warfarin metabolism of acetaminophen metabolism of clozapine metabolism of imipramine metabolism of olanzapine metabolism of propranolol metabolism of tacrine metabolism of theophylline metabolism of warfarin |
| gptkbp:cofactor |
hemoglobin
|
| gptkbp:EC_number |
1.14.14.1
|
| gptkbp:encodedBy |
CYP1A2 gene
|
| gptkbp:Entrez_Gene_ID |
GC01M124060
|
| gptkbp:expressedIn |
liver
|
| gptkbp:function |
detoxification
drug metabolism bioactivation of procarcinogens |
| gptkbp:gene |
gptkb:CYP1A2
|
| gptkbp:HGNC_ID |
2596
|
| https://www.w3.org/2000/01/rdf-schema#label |
cytochrome P450 1A2
|
| gptkbp:inducedBy |
gptkb:omeprazole
smoking polycyclic aromatic hydrocarbons cruciferous vegetables |
| gptkbp:inhibitedBy |
gptkb:fluvoxamine
cimetidine ciprofloxacin amiodarone |
| gptkbp:locatedIn |
gptkb:endoplasmic_reticulum
|
| gptkbp:locatedOnChromosome |
chromosome 15q24.1
|
| gptkbp:member |
gptkb:cytochrome_P450_superfamily
|
| gptkbp:molecularWeight |
58 kDa
|
| gptkbp:OMIM |
124060
|
| gptkbp:PDB |
2HI4
|
| gptkbp:RefSeq |
NM_000761
|
| gptkbp:substrate |
gptkb:theophylline
gptkb:R-warfarin gptkb:tacrine gptkb:aflatoxin_B1 gptkb:imipramine gptkb:clozapine gptkb:olanzapine caffeine propranolol acetaminophen phenacetin aromatic amines heterocyclic amines |
| gptkbp:UniProtID |
gptkb:P05177
|
| gptkbp:bfsParent |
gptkb:CYP1A2
|
| gptkbp:bfsLayer |
5
|