P05177

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:PAI-1
Endothelial plasminogen activator inhibitor
Serpin E1
gptkbp:associatedWith gptkb:metabolic_syndrome
myocardial infarction
fibrosis
thrombophilia
gptkbp:Entrez_Gene_ID gptkb:ENSG00000106366
5054
gptkbp:enzymeCommissionNumber EC 3.4.21.-
gptkbp:expressedIn upregulated by hypoxia
upregulated by cytokines
upregulated by TGF-beta
gptkbp:family serpin superfamily
gptkbp:function inhibits tissue plasminogen activator and urokinase
gptkbp:gene gptkb:SERPINE1
gptkbp:HGNC_ID gptkb:HGNC:8583
https://www.w3.org/2000/01/rdf-schema#label P05177
gptkbp:InterPro IPR023796
gptkbp:KEGGID hsa:5054
gptkbp:length 402 amino acids
gptkbp:locatedOnChromosome 7q22.1
gptkbp:location extracellular space
gptkbp:molecularWeight 45,000 Da
gptkbp:mutationAssociatedWith associated with increased risk of thrombosis
gptkbp:OMIM 173360
gptkbp:organism gptkb:Homo_sapiens
gptkbp:PDB 1B3K
1DVN
1EZX
1LJ5
1OC0
1OCO
1YXA
gptkbp:postTranslationalModification phosphorylation
glycosylation
gptkbp:protein_name Plasminogen activator inhibitor 1
gptkbp:proteinFamily PF00079
gptkbp:Reactome R-HSA-140875
gptkbp:RefSeq NP_000592.1
gptkbp:sequenceStatus complete
gptkbp:significance marker for metabolic syndrome
marker for cardiovascular disease
gptkbp:subcellularLocation secreted
gptkbp:tissue_specificity expressed in liver, platelets, endothelium
gptkbp:UniGene Hs.654
gptkbp:UniProtID gptkb:P05177
gptkbp:bfsParent gptkb:CYP1A2
gptkbp:bfsLayer 5