|
gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PAI-1
Endothelial plasminogen activator inhibitor
Serpin E1
|
|
gptkbp:associatedWith
|
gptkb:thrombophilia
gptkb:metabolic_syndrome
myocardial infarction
fibrosis
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000106366
5054
|
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gptkbp:enzymeCommissionNumber
|
EC 3.4.21.-
|
|
gptkbp:expressedIn
|
upregulated by hypoxia
upregulated by cytokines
upregulated by TGF-beta
|
|
gptkbp:family
|
serpin superfamily
|
|
gptkbp:function
|
inhibits tissue plasminogen activator and urokinase
|
|
gptkbp:gene
|
gptkb:SERPINE1
|
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gptkbp:HGNC_ID
|
gptkb:HGNC:8583
|
|
gptkbp:InterPro
|
IPR023796
|
|
gptkbp:KEGGID
|
hsa:5054
|
|
gptkbp:length
|
402 amino acids
|
|
gptkbp:locatedOnChromosome
|
7q22.1
|
|
gptkbp:location
|
extracellular space
|
|
gptkbp:molecularWeight
|
45,000 Da
|
|
gptkbp:mutationAssociatedWith
|
associated with increased risk of thrombosis
|
|
gptkbp:OMIM
|
173360
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
1B3K
1DVN
1EZX
1LJ5
1OC0
1OCO
1YXA
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:protein_name
|
Plasminogen activator inhibitor 1
|
|
gptkbp:proteinFamily
|
PF00079
|
|
gptkbp:Reactome
|
R-HSA-140875
|
|
gptkbp:RefSeq
|
NP_000592.1
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:significance
|
marker for metabolic syndrome
marker for cardiovascular disease
|
|
gptkbp:subcellularLocation
|
secreted
|
|
gptkbp:tissue_specificity
|
expressed in liver, platelets, endothelium
|
|
gptkbp:UniGene
|
Hs.654
|
|
gptkbp:UniProtID
|
gptkb:P05177
|
|
gptkbp:bfsParent
|
gptkb:CYP1A2
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P05177
|