Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:activatedBy |
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases |
| gptkbp:catalyzes |
phosphorylation of phosphatidylinositol (4,5)-bisphosphate (PIP2)
|
| gptkbp:discoveredBy |
gptkb:Lewis_Cantley
|
| gptkbp:foundIn |
eukaryotic cells
|
| gptkbp:gene |
gptkb:PIK3CA
gptkb:PIK3CB gptkb:PIK3CD gptkb:PIK3CG |
| gptkbp:hasIsoform |
gptkb:PI3K_beta
gptkb:PI3K_gamma gptkb:PI3K_delta gptkb:PI3K_alpha |
| https://www.w3.org/2000/01/rdf-schema#label |
class I PI3K
|
| gptkbp:inhibitedBy |
PI3K inhibitors
|
| gptkbp:involvedIn |
cell proliferation
cell survival metabolism cell growth cancer signaling pathways |
| gptkbp:product |
gptkb:phosphatidylinositol_(3,4,5)-trisphosphate_(PIP3)
|
| gptkbp:regulates |
gptkb:AKT_signaling_pathway
|
| gptkbp:subunit |
regulatory subunit
p110 catalytic subunit |
| gptkbp:bfsParent |
gptkb:protein
|
| gptkbp:bfsLayer |
4
|