|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
Cdc25 phosphatase
|
|
gptkbp:alsoKnownAs
|
gptkb:CDK1
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:discoveredBy
|
gptkb:Paul_Nurse
|
|
gptkbp:encodedBy
|
gptkb:CDK1_gene
|
|
gptkbp:enzymeClassification
|
serine/threonine-protein kinase
|
|
gptkbp:expressedIn
|
all proliferating cells
|
|
gptkbp:formsComplexWith
|
gptkb:cyclin_A
gptkb:cyclin_B
|
|
gptkbp:function
|
cell cycle regulation
mitosis
G2/M transition
|
|
gptkbp:gene
|
gptkb:CDK1
|
|
gptkbp:GO_term
|
GO:0004693
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
cdc2
|
|
gptkbp:inhibitedBy
|
gptkb:purvalanol_A
gptkb:flavopiridol
gptkb:p21
gptkb:p27
gptkb:roscovitine
gptkb:p57
Wee1 kinase
alvocidib
dinaciclib
SNS-032
olomoucine
|
|
gptkbp:locatedOnChromosome
|
chromosome 10q21.2
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:mutationAssociatedWith
|
cell cycle arrest
|
|
gptkbp:OMIM
|
116940
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
Saccharomyces pombe
|
|
gptkbp:pathway
|
cell cycle pathway
|
|
gptkbp:PDB
|
gptkb:4Y72
6GU2
|
|
gptkbp:phosphorylates
|
Tyr15
Thr14
Thr161
|
|
gptkbp:regulates
|
cytokinesis
chromosome condensation
mitotic entry
nuclear envelope breakdown
spindle assembly
|
|
gptkbp:requires
|
cell division
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P06493
|
|
gptkbp:bfsParent
|
gptkb:yeast
|
|
gptkbp:bfsLayer
|
4
|