|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:p34_protein_kinase
gptkb:CDC2
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:component
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:dephosphorylatedBy
|
gptkb:CDC25C
|
|
gptkbp:encodes
|
gptkb:Cyclin-dependent_kinase_1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000170312
983
|
|
gptkbp:expressedIn
|
all proliferating cells
|
|
gptkbp:function
|
regulation of cell cycle
protein serine/threonine kinase activity
phosphorylation of proteins
G2/M transition of mitotic cell cycle
|
|
gptkbp:GOProcess
|
mitotic cell cycle
|
|
gptkbp:HGNC_ID
|
HGNC:1722
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDK1 gene
|
|
gptkbp:inhibitedBy
|
Flavopiridol
RO-3306
|
|
gptkbp:interactsWith
|
gptkb:CDC25C
gptkb:Cyclin_B1
Cyclin A2
Wee1
|
|
gptkbp:length
|
297 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
gptkb:10q21.2
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:mutationAssociatedWith
|
intellectual disability
microcephaly
|
|
gptkbp:OMIM
|
116940
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cdk1
|
|
gptkbp:orthologInYeast
|
gptkb:CDC28
|
|
gptkbp:PDB
|
gptkb:4Y72
5HQ0
6GU2
|
|
gptkbp:phosphorylates
|
Wee1
|
|
gptkbp:regulates
|
DNA replication
mitosis
chromosome condensation
nuclear envelope breakdown
spindle assembly
|
|
gptkbp:requires
|
cell division
entry into mitosis
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProt
|
|
gptkbp:UniProtID
|
gptkb:P06493
|
|
gptkbp:bfsParent
|
gptkb:cdc2
|
|
gptkbp:bfsLayer
|
5
|