Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:E-cadherin
|
| gptkbp:category |
cell surface receptor
transmembrane protein |
| gptkbp:encodedBy |
gptkb:CDH1_gene
|
| gptkbp:expressedIn |
epithelial tissues
|
| gptkbp:foundIn |
humans
other mammals |
| gptkbp:function |
cell adhesion
maintenance of epithelial cell layers |
| gptkbp:HGNC_ID |
1748
|
| https://www.w3.org/2000/01/rdf-schema#label |
cadherin 1
|
| gptkbp:interactsWith |
gptkb:alpha-catenin
gptkb:p120-catenin gptkb:beta-catenin |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_16
16q22.1 |
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:lossOfFunctionLeadsTo |
metastasis
increased cell invasion |
| gptkbp:mutationAssociatedWith |
gptkb:hereditary_diffuse_gastric_cancer
gptkb:lobular_breast_cancer |
| gptkbp:OMIM |
192090
|
| gptkbp:role |
tumor suppression
|
| gptkbp:structure |
single-pass transmembrane protein
|
| gptkbp:UniProtID |
P12830
|
| gptkbp:bfsParent |
gptkb:CDH1
|
| gptkbp:bfsLayer |
7
|