|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:E-cadherin
|
|
gptkbp:associatedWith
|
gptkb:Barrett's_esophagus
colorectal cancer
prostate cancer
epithelial-mesenchymal transition
|
|
gptkbp:clinicalTrialPhase
|
immunohistochemistry
|
|
gptkbp:discoveredBy
|
gptkb:Masatoshi_Takeichi
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:encodedBy
|
gptkb:CDH1_gene
|
|
gptkbp:expressedIn
|
epithelial tissues
|
|
gptkbp:family
|
gptkb:cadherin_superfamily
|
|
gptkbp:foundIn
|
humans
other mammals
|
|
gptkbp:function
|
cell-cell adhesion
maintenance of epithelial cell layers
|
|
gptkbp:GO
|
GO:0007155
|
|
gptkbp:HGNC_ID
|
1748
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
cadherin-1
|
|
gptkbp:interactsWith
|
gptkb:alpha-catenin
gptkb:p120-catenin
gptkb:beta-catenin
|
|
gptkbp:involvedIn
|
embryonic development
wound healing
cell signaling
adherens junction formation
|
|
gptkbp:locatedOnChromosome
|
16q22.1
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:lossOfFunctionLeadsTo
|
increased cancer metastasis
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hereditary_diffuse_gastric_cancer
gptkb:lobular_breast_cancer
|
|
gptkbp:OMIM
|
192090
|
|
gptkbp:orthologIn
|
gptkb:meat
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:pathway
|
gptkb:Wnt_signaling_pathway
cell adhesion molecules pathway
|
|
gptkbp:PDB
|
2O72
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
calcium-dependent
|
|
gptkbp:role
|
tumor suppression
|
|
gptkbp:sequence
|
882 amino acids
|
|
gptkbp:structure
|
transmembrane protein
extracellular cadherin repeats
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
|
|
gptkbp:UniProtID
|
P12830
|
|
gptkbp:usedAs
|
diagnostic marker for carcinoma
|
|
gptkbp:bfsParent
|
gptkb:E-cadherin
|
|
gptkbp:bfsLayer
|
6
|