|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
BMP2B
BMP2B homolog
ZYME
|
|
gptkbp:associatedWith
|
gptkb:fibrodysplasia_ossificans_progressiva
microphthalmia
orofacial cleft
|
|
gptkbp:discoveredBy
|
gptkb:Wozney_et_al.
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:encodes
|
BMP4 protein
|
|
gptkbp:Entrez_Gene_ID
|
652
|
|
gptkbp:expressedIn
|
embryonic tissues
|
|
gptkbp:fullName
|
Bone morphogenetic protein 4
|
|
gptkbp:function
|
apoptosis
cell differentiation
embryonic development
regulation of bone and cartilage development
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
1071
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BMP4
|
|
gptkbp:inhibitedBy
|
gptkb:Chordin
gptkb:Follistatin
gptkb:Noggin
|
|
gptkbp:interactsWith
|
gptkb:Chordin
gptkb:Noggin
gptkb:Gremlin
|
|
gptkbp:length
|
408 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_14
14q22-q23
|
|
gptkbp:memberOf
|
gptkb:TGF-beta_superfamily
|
|
gptkbp:molecularWeight
|
46 kDa
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
|
|
gptkbp:OMIM
|
112262
|
|
gptkbp:orthologInMouse
|
Bmp4
|
|
gptkbp:pathway
|
gptkb:BMP_signaling_pathway
gptkb:TGF-beta_signaling_pathway
SMAD signaling pathway
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:product
|
secreted signaling molecule
|
|
gptkbp:recipient
|
gptkb:BMPR1A
gptkb:BMPR1B
gptkb:BMPR2
|
|
gptkbp:regulates
|
eye development
kidney development
lung development
hair follicle development
limb development
tooth development
mesoderm induction
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
P12644
|
|
gptkbp:bfsParent
|
gptkb:TGF-beta_superfamily
gptkb:bone_morphogenetic_proteins
gptkb:BMPR1A
gptkb:chordin
|
|
gptkbp:bfsLayer
|
7
|