|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:Growth_Differentiation_Factor_2
gptkb:GDF-2
|
|
gptkbp:associatedWith
|
gptkb:hereditary_hemorrhagic_telangiectasia
pulmonary arterial hypertension
|
|
gptkbp:cleavage
|
between Arg320 and Asp321 (human)
|
|
gptkbp:component
|
extracellular region
|
|
gptkbp:discoveredBy
|
gptkb:Wozney_et_al.
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:Entrez_Gene_ID
|
2658
|
|
gptkbp:expressedIn
|
gptkb:bone
liver
endothelial cells
|
|
gptkbp:fullName
|
gptkb:Bone_Morphogenetic_Protein_9
|
|
gptkbp:function
|
growth factor activity
induces bone and cartilage development
involved in liver development
regulates angiogenesis
|
|
gptkbp:gene
|
gptkb:GDF2
|
|
gptkbp:GOProcess
|
angiogenesis
osteoblast differentiation
|
|
gptkbp:HGNC_ID
|
4222
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BMP9
|
|
gptkbp:inhibitedBy
|
gptkb:ALK1-Fc
gptkb:soluble_endoglin
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q11.22_(human)
|
|
gptkbp:memberOf
|
gptkb:TGF-beta_superfamily
|
|
gptkbp:molecularWeight
|
12 kDa (mature form)
42 kDa (precursor)
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
|
|
gptkbp:orthologIn
|
gptkb:mouse_Bmp9
gptkb:rat_Bmp9
|
|
gptkbp:PDB
|
gptkb:4YCG
gptkb:4YCI
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:recipient
|
gptkb:ALK1
gptkb:ALK2
gptkb:ActRIIB
|
|
gptkbp:regulates
|
hepcidin expression
iron homeostasis
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:UniProt
|
|
gptkbp:sequence
|
429 amino acids (human precursor)
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:structure
|
dimeric protein
|
|
gptkbp:UniProtID
|
Q9UK05
|
|
gptkbp:bfsParent
|
gptkb:GDF2
|
|
gptkbp:bfsLayer
|
6
|