Statements (42)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:G_protein-coupled_receptor |
| gptkbp:discoveredBy |
gptkb:Raymond_Ahlquist
|
| gptkbp:discoveredIn |
1948
|
| gptkbp:effect |
analgesia
inhibits insulin secretion decreases cAMP levels causes vasoconstriction decreases sympathetic outflow induces sedation |
| gptkbp:encodedBy |
gptkb:ADRA2A_gene
gptkb:ADRA2B_gene gptkb:ADRA2C_gene |
| gptkbp:enemyOf |
gptkb:dexmedetomidine
gptkb:clonidine gptkb:yohimbine gptkb:brimonidine guanfacine idazoxan |
| gptkbp:foundIn |
gptkb:pancreatic_islets
central nervous system peripheral nervous system platelets vascular smooth muscle |
| gptkbp:function |
inhibits adenylate cyclase
inhibits norepinephrine release modulates sympathetic nervous system |
| https://www.w3.org/2000/01/rdf-schema#label |
alpha-2 adrenergic receptor
|
| gptkbp:ligand |
norepinephrine
epinephrine |
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:medicalUse |
glaucoma treatment
sedation ADHD treatment antihypertensive therapy |
| gptkbp:subclassOf |
adrenergic receptor
|
| gptkbp:subspecies |
alpha-2A adrenergic receptor
alpha-2B adrenergic receptor alpha-2C adrenergic receptor |
| gptkbp:type |
gptkb:Gi_protein
|
| gptkbp:bfsParent |
gptkb:alpha-adrenergic_receptors
|
| gptkbp:bfsLayer |
7
|