|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
ADRA2
alpha-2A adrenergic receptor
alpha-2A adrenoceptor
|
|
gptkbp:associatedWith
|
gptkb:attention_deficit_hyperactivity_disorder
gptkb:type_2_diabetes
hypertension
|
|
gptkbp:discoveredBy
|
gene cloning
|
|
gptkbp:encodes
|
Alpha-2A adrenergic receptor
|
|
gptkbp:Entrez_Gene_ID
|
150
ENSG00000150594
GC10P112505
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
pancreas
vascular smooth muscle
|
|
gptkbp:firstDescribed
|
1987
|
|
gptkbp:fullName
|
adrenoceptor alpha 2A
|
|
gptkbp:function
|
G protein-coupled receptor activity
adrenergic receptor activity, alpha2-adrenergic receptor activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
rs1800544
rs553668
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:282
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ADRA2A gene
|
|
gptkbp:involvedIn
|
vasoconstriction
regulation of neurotransmitter release
regulation of insulin secretion
|
|
gptkbp:length
|
450 amino acids
|
|
gptkbp:locatedOnChromosome
|
10
10q25.2
|
|
gptkbp:MIM_Number
|
104210
|
|
gptkbp:mutationAssociatedWith
|
autonomic dysfunction
psychiatric disorders
|
|
gptkbp:OMIM
|
104210
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Adra2a
|
|
gptkbp:proteinFamily
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:RefSeq
|
NM_000681
|
|
gptkbp:regulates
|
sympathetic nervous system
neurotransmitter release
insulin secretion
|
|
gptkbp:targetOfDrug
|
gptkb:dexmedetomidine
gptkb:clonidine
gptkb:yohimbine
guanfacine
|
|
gptkbp:UniProtID
|
P08913
|
|
gptkbp:bfsParent
|
gptkb:alpha-adrenergic_receptors
|
|
gptkbp:bfsLayer
|
7
|