Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:von_Hippel–Lindau_disease
clear cell renal cell carcinoma |
| gptkbp:discoveredBy |
gptkb:Gregg_L._Semenza
gptkb:Peter_J._Ratcliffe gptkb:William_Kaelin_Jr. |
| gptkbp:encodedBy |
gptkb:VHL_gene
|
| gptkbp:fullName |
von Hippel–Lindau tumor suppressor protein
|
| gptkbp:function |
tumor suppressor
regulation of hypoxia-inducible factors (HIFs) |
| https://www.w3.org/2000/01/rdf-schema#label |
pVHL
|
| gptkbp:interactsWith |
gptkb:HIF-1α
gptkb:RBX1 elongin B elongin C CUL2 |
| gptkbp:length |
213 amino acids
|
| gptkbp:locatedOnChromosome |
3p25-26
|
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:molecularWeight |
30 kDa
|
| gptkbp:organism |
gptkb:human
|
| gptkbp:PDB |
gptkb:1LM8
|
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination |
| gptkbp:UniProtID |
P40337
|
| gptkbp:bfsParent |
gptkb:von_Hippel-Lindau_protein_(VHL)
gptkb:Von_Hippel-Lindau_tumor_suppressor |
| gptkbp:bfsLayer |
7
|