|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
RING-box protein 1
ROC1
Regulator of cullins 1
|
|
gptkbp:associatedWith
|
gptkb:cancer
protein ubiquitination
proteasomal degradation
|
|
gptkbp:component
|
gptkb:SCF_ubiquitin_ligase_complex
Cullin-RING ubiquitin ligase complex
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:domain
|
RING finger domain
|
|
gptkbp:encodes
|
RING-box protein 1
|
|
gptkbp:Entrez_Gene_ID
|
8737
ENSG00000143507
|
|
gptkbp:expressedIn
|
various human tissues
|
|
gptkbp:function
|
E3 ubiquitin ligase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:10019
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RBX1
|
|
gptkbp:interactsWith
|
gptkb:CUL4A
CUL1
CUL2
CUL3
CUL4B
CUL5
SKP1
UBE2D2
|
|
gptkbp:locatedIn
|
human genome
|
|
gptkbp:locatedOnChromosome
|
chromosome 22
|
|
gptkbp:molecularWeight
|
12 kDa
|
|
gptkbp:OMIM
|
603474
|
|
gptkbp:orthologInMouse
|
Rbx1
|
|
gptkbp:orthologInYeast
|
Hrt1
|
|
gptkbp:PDB
|
1LDK
|
|
gptkbp:requires
|
embryonic development
cell cycle progression
|
|
gptkbp:UniProtID
|
Q9UBF6
|
|
gptkbp:bfsParent
|
gptkb:SCF(SKP2)_complex
gptkb:Cullin-RING_ubiquitin_ligases
gptkb:von_Hippel-Lindau_protein_(VHL)
gptkb:Von_Hippel-Lindau_tumor_suppressor
|
|
gptkbp:bfsLayer
|
7
|