|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:A20
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
autoimmune diseases
psoriasis
rheumatoid arthritis
|
|
gptkbp:biologicalProcess
|
E3 ubiquitin ligase activity
deubiquitinase activity
|
|
gptkbp:domain
|
zinc finger domain
OTU domain
|
|
gptkbp:encodedBy
|
gptkb:TNFAIP3_gene
|
|
gptkbp:Entrez_Gene_ID
|
7128
ENSG00000118503
|
|
gptkbp:expressedIn
|
immune cells
epithelial cells
|
|
gptkbp:firstDescribed
|
1990
|
|
gptkbp:function
|
negative regulator of NF-kappaB signaling
ubiquitin-editing enzyme
|
|
gptkbp:HGNC_ID
|
HGNC:11830
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNFAIP3 protein
|
|
gptkbp:interactsWith
|
gptkb:TRAF6
gptkb:IKK_complex
gptkb:TRAF2
gptkb:NEMO
gptkb:RIPK1
|
|
gptkbp:involvedIn
|
immune response
inflammatory response
|
|
gptkbp:length
|
790 amino acids
|
|
gptkbp:locatedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:6q23
|
|
gptkbp:mutationAssociatedWith
|
leukemia
autoimmunity
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
3ZJD
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:NF-kappaB_pathway
apoptosis
cell survival
inflammatory cytokine production
TNF-induced apoptosis
|
|
gptkbp:UniProtID
|
P21580
|
|
gptkbp:bfsParent
|
gptkb:A20_protein
|
|
gptkbp:bfsLayer
|
7
|