hereditary nonpolyposis colorectal cancer
GPTKB entity
Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:healthcare_organization
|
| gptkbp:bfsLayer |
4
|
| gptkbp:bfsParent |
gptkb:secondary_glioblastoma
|
| gptkbp:associated_with |
gptkb:healthcare_organization
gptkb:Lynch_syndrome gptkb:bile_duct_cancer ovarian cancer stomach cancer brain tumors other cancers small intestine cancer urinary tract cancer sebaceous gland tumors |
| gptkbp:descendant |
autosomal dominant
|
| gptkbp:first_described_by |
gptkb:1993
|
| gptkbp:genetic_diversity |
ML H1, MS H2, MS H6, PM S2
mutations in mismatch repair genes |
| https://www.w3.org/2000/01/rdf-schema#label |
hereditary nonpolyposis colorectal cancer
|
| gptkbp:is_popular_in |
1 in 300
|
| gptkbp:is_protected_by |
lifestyle changes
regular screening |
| gptkbp:lifespan |
up to 10% for stomach cancer
up to 15% for ovarian cancer up to 5% for bile duct cancer up to 5% for brain tumors up to 5% for pancreatic cancer up to 5% for sebaceous gland tumors up to 5% for skin cancer up to 5% for small intestine cancer up to 5% for urinary tract cancer up to 60% for endometrial cancer up to 80% for colorectal cancer |
| gptkbp:provides_information_on |
gptkb:American_College_of_Gastroenterology
gptkb:European_Society_for_Medical_Oncology gptkb:American_Society_of_Clinical_Oncology gptkb:National_Comprehensive_Cancer_Network Society of Surgical Oncology |
| gptkbp:research_focus |
patient education
early detection genetic counseling family planning treatment options |
| gptkbp:risk_factor |
family history
|
| gptkbp:screenings |
beginning at age 20-25
|
| gptkbp:social_responsibility |
genetic testing
|
| gptkbp:symptoms |
endometrial cancer
colorectal tumors |
| gptkbp:treatment |
gptkb:hospital
radiation therapy chemotherapy |