hereditary nonpolyposis colorectal cancer

GPTKB entity

Statements (34)
Predicate Object
gptkbp:instanceOf genetic disorder
syndrome
gptkbp:affects colon
rectum
gptkbp:alsoKnownAs gptkb:Lynch_syndrome
gptkb:HNPCC
gptkbp:category hereditary cancer syndrome
gptkbp:diagnosedBy gptkb:Amsterdam_criteria
gptkb:Bethesda_guidelines
genetic testing
gptkbp:firstDescribed gptkb:Henry_T._Lynch
https://www.w3.org/2000/01/rdf-schema#label hereditary nonpolyposis colorectal cancer
gptkbp:ICD-10_code gptkb:C18
gptkbp:inheritsFrom autosomal dominant
gptkbp:mutationAssociatedWith gptkb:MLH1
gptkb:MSH2
gptkb:MSH6
gptkb:PMS2
gptkb:EPCAM
gptkbp:OMIM 120435
gptkbp:prevalence 2-4% of all colorectal cancers
gptkbp:riskFactor gptkb:cancer
gptkb:endometrial_cancer
colorectal cancer
stomach cancer
urinary tract cancer
gptkbp:symptom family history of cancer
early-onset colorectal cancer
gptkbp:treatment chemotherapy
prophylactic surgery
regular colonoscopy
gptkbp:bfsParent gptkb:Lynch_syndrome
gptkb:endometrial_cancer
gptkbp:bfsLayer 5