|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:TGF-beta_receptor_type_I
|
|
gptkbp:associatedWith
|
gptkb:cancer
fibrosis
|
|
gptkbp:discoveredBy
|
1993
|
|
gptkbp:domain
|
serine/threonine kinase domain
GS domain
|
|
gptkbp:encodedBy
|
gptkb:TGFBR1_gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.30
|
|
gptkbp:formsComplexWith
|
gptkb:TGF-beta_receptor_type_II
|
|
gptkbp:function
|
mediates TGF-beta signaling
serine/threonine kinase receptor
|
|
gptkbp:gene
|
gptkb:TGFBR1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ALK5
|
|
gptkbp:inhibitedBy
|
LY2157299
SB-431542
|
|
gptkbp:ligand
|
gptkb:TGF-beta
|
|
gptkbp:locatedOnChromosome
|
gptkb:9q22
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~56 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Loeys-Dietz_syndrome
gptkb:hereditary_hemorrhagic_telangiectasia
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:phosphorylates
|
gptkb:SMAD2
gptkb:SMAD3
|
|
gptkbp:structure
|
single-pass type I membrane protein
|
|
gptkbp:UniProtID
|
P36897
|
|
gptkbp:bfsParent
|
gptkb:TGF-beta_receptor_family
|
|
gptkbp:bfsLayer
|
7
|