|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:SOD
gptkb:Cu/Zn_SOD
gptkb:Fe_SOD
gptkb:Mn_SOD
|
|
gptkbp:associatedWith
|
gptkb:Down_syndrome
gptkb:cancer
gptkb:cardiovascular_disease
amyotrophic lateral sclerosis
|
|
gptkbp:cofactor
|
copper
iron
zinc
manganese
|
|
gptkbp:discoveredBy
|
gptkb:Joe_McCord
gptkb:Irwin_Fridovich
|
|
gptkbp:discoveredIn
|
1969
|
|
gptkbp:EC_number
|
1.15.1.1
|
|
gptkbp:foundIn
|
chloroplasts
mitochondria
cytosol
aerobic organisms
|
|
gptkbp:function
|
catalyzes dismutation of superoxide into oxygen and hydrogen peroxide
|
|
gptkbp:gene
|
gptkb:SOD2
gptkb:SOD3
gptkb:SOD1
|
|
gptkbp:GO_term
|
gptkb:GO:0004784
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Superoxide dismutase
|
|
gptkbp:inhibitedBy
|
gptkb:diethyldithiocarbamate
cyanide
|
|
gptkbp:locatedOnChromosome
|
21q22.11 (SOD1 in humans)
4p15.3-p15.1 (SOD3 in humans)
6q25.3 (SOD2 in humans)
|
|
gptkbp:molecularWeight
|
~22 kDa (SOD2)
~32 kDa (SOD1)
|
|
gptkbp:OMIM
|
147450
|
|
gptkbp:PDB
|
gptkb:1CB4
|
|
gptkbp:presentIn
|
gptkb:Bacteria
animals
fungi
plants
|
|
gptkbp:product
|
hydrogen peroxide
oxygen
|
|
gptkbp:role
|
antioxidant defense
|
|
gptkbp:significance
|
mutations linked to amyotrophic lateral sclerosis
|
|
gptkbp:structure
|
homodimer or homotetramer
|
|
gptkbp:substrate
|
superoxide radical
|
|
gptkbp:UniProtID
|
gptkb:P00441
|
|
gptkbp:usedIn
|
therapeutic research
biochemical assays
antioxidant research
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|