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gptkbp:instanceOf
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gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:SOD2
gptkb:Mitochondrial_superoxide_dismutase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
amyotrophic lateral sclerosis
|
|
gptkbp:cofactor
|
manganese
|
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gptkbp:discoveredBy
|
gptkb:Irwin_Fridovich
|
|
gptkbp:discoveredIn
|
1969
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gptkbp:EC_number
|
1.15.1.1
|
|
gptkbp:foundIn
|
eukaryotes
some prokaryotes
|
|
gptkbp:fullName
|
gptkb:Manganese_superoxide_dismutase
|
|
gptkbp:function
|
catalyzes the dismutation of superoxide radicals to oxygen and hydrogen peroxide
|
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gptkbp:gene
|
gptkb:SOD2
|
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gptkbp:GO_term
|
GO:0004789
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Mn SOD
|
|
gptkbp:importantFor
|
protects cells from oxidative stress
|
|
gptkbp:inhibitedBy
|
gptkb:diethyldithiocarbamate
hydroxylamine
|
|
gptkbp:locatedOnChromosome
|
chromosome 6q25 in humans
|
|
gptkbp:location
|
mitochondria
|
|
gptkbp:molecularWeight
|
~96 kDa (tetramer)
|
|
gptkbp:PDB
|
gptkb:1LUV
|
|
gptkbp:product
|
hydrogen peroxide (H2O2)
oxygen (O2)
|
|
gptkbp:role
|
antioxidant defense
|
|
gptkbp:structure
|
homotetramer in humans
|
|
gptkbp:substrate
|
superoxide anion (O2−)
|
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gptkbp:UniProtID
|
P04179
|
|
gptkbp:bfsParent
|
gptkb:Superoxide_dismutase
|
|
gptkbp:bfsLayer
|
7
|