Sp1 transcription factor

GPTKB entity

Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
transcription factor
gptkbp:alternativeName gptkb:SP1
Specificity protein 1
Transcription factor Sp1
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes
gptkbp:discoveredBy 1983
gptkbp:DNA_binding_domain zinc finger
gptkbp:Entrez_Gene_ID 6667
ENSG00000185591
gptkbp:expressedIn most tissues
gptkbp:function regulation of gene expression
binds GC-rich motifs
gptkbp:gene gptkb:SP1
gptkbp:homologs_in gptkb:mouse
gptkb:zebrafish
gptkb:Drosophila_melanogaster
right
https://www.w3.org/2000/01/rdf-schema#label Sp1 transcription factor
gptkbp:interactsWith gptkb:CBP/p300
gptkb:TATA-binding_protein
gptkb:c-Myc
gptkb:E2F1
gptkb:HDAC1
gptkb:p53
gptkb:NF-κB
gptkbp:locatedOnChromosome 12q13.1
gptkbp:molecularWeight ~81 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:PDB 1SP1
gptkbp:postTranslationalModification phosphorylation
glycosylation
sumoylation
acetylation
gptkbp:regulates methylation
oxidative stress
ubiquitination
housekeeping genes
apoptosis genes
cell cycle genes
proteasomal degradation
immune response genes
gptkbp:UniProtID P08047
gptkbp:bfsParent gptkb:SP1_gene
gptkbp:bfsLayer 8