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gptkbp:instanceOf
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gptkb:protein
hormone
|
|
gptkbp:abbreviation
|
gptkb:IGF-1
|
|
gptkbp:affects
|
bone growth
muscle growth
organ size
cartilage growth
|
|
gptkbp:binds
|
gptkb:IGF-1_receptor
gptkb:IGF-binding_proteins
|
|
gptkbp:category
|
growth factor
peptide
|
|
gptkbp:discoveredBy
|
D.R. Clemmons
J.L. Van Wyk
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:foundIn
|
blood plasma
|
|
gptkbp:function
|
stimulates cell proliferation
stimulates systemic body growth
inhibits cell death (apoptosis)
|
|
gptkbp:gene
|
gptkb:IGF1
|
|
gptkbp:halfLife
|
about 12-15 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Somatomedin-C
|
|
gptkbp:inhibitedBy
|
chronic illness
malnutrition
insulin deficiency
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12_(human)
|
|
gptkbp:measures
|
immunoassay
|
|
gptkbp:medicalUse
|
diagnosis of growth disorders
marker for growth hormone activity
monitoring acromegaly
monitoring gigantism
|
|
gptkbp:molecularWeight
|
about 7.6 kDa
|
|
gptkbp:otherName
|
gptkb:Insulin-like_growth_factor_1
|
|
gptkbp:producedBy
|
liver
other tissues
|
|
gptkbp:promotion
|
recombinant human growth hormone
|
|
gptkbp:recipient
|
gptkb:IGF1R
|
|
gptkbp:regulates
|
development
metabolism
cellular growth
|
|
gptkbp:relatedTo
|
gptkb:Insulin
gptkb:Insulin-like_growth_factor_2
|
|
gptkbp:sequence
|
70 amino acids
|
|
gptkbp:structure
|
single-chain polypeptide
|
|
gptkbp:bfsParent
|
gptkb:Somatomedin-A
|
|
gptkbp:bfsLayer
|
8
|