Smoothened (SMO) receptor

URI: https://gptkb.org/entity/Smoothened_(SMO)_receptor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:G_protein-coupled_receptor
gptkbp:activatedBy	by Hedgehog ligand
gptkbp:alternativeName	gptkb:SMO Smoothened homolog SMOH
gptkbp:associatedWith	gptkb:cancer gptkb:medulloblastoma gptkb:rhabdomyosarcoma gptkb:Gorlin_syndrome basal cell carcinoma
gptkbp:biologicalProcess	cell proliferation embryonic development tissue patterning
gptkbp:encodedBy	SMO gene
gptkbp:Entrez_Gene_ID	6608 ENSG00000128602
gptkbp:function	signal transduction
https://www.w3.org/2000/01/rdf-schema#label	Smoothened (SMO) receptor
gptkbp:interactsWith	gptkb:GLI_transcription_factors SUFU Patched (PTCH1)
gptkbp:involvedIn	gptkb:Hedgehog_signaling_pathway
gptkbp:locatedIn	gptkb:cell_membrane
gptkbp:locatedOnChromosome	chromosome 7q32.1
gptkbp:molecularWeight	86 kDa
gptkbp:mutationAssociatedWith	D473H L412F W535L
gptkbp:OMIM	601500
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	Drosophila Smoothened protein
gptkbp:pathway	canonical Hedgehog pathway non-canonical Hedgehog pathway
gptkbp:PDB	4JKV 4N4W 5L7D
gptkbp:pharmacological_inhibitor	gptkb:GDC-0449 gptkb:cyclopamine LDE225
gptkbp:postTranslationalModification	phosphorylation glycosylation
gptkbp:RefSeq	NM_005631
gptkbp:regulates	inhibited by Patched (PTCH1)
gptkbp:structure	7 transmembrane domains
gptkbp:target	gptkb:sonidegib gptkb:vismodegib glasdegib
gptkbp:UniProtID	Q99835
gptkbp:bfsParent	gptkb:vismodegib gptkb:GDC-0449
gptkbp:bfsLayer	8