aspartic protease

GPTKB entity

Statements (29)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activeSiteResidue aspartic acid residues
gptkbp:catalyzes hydrolysis of peptide bonds
gptkbp:compatibleWith metal ions for activity
gptkbp:enzymeCommissionNumber EC 3.4.23
gptkbp:example gptkb:renin
pepsin
cathepsin D
HIV-1 protease
gptkbp:foundIn gptkb:Bacteria
animals
fungi
plants
https://www.w3.org/2000/01/rdf-schema#label aspartic protease
gptkbp:inhibitedBy pepstatin
gptkbp:mechanismOfAction general acid-base catalysis
gptkbp:molecular_weight_range 30-50 kDa
gptkbp:optimum_pH acidic
gptkbp:requires water for catalysis
gptkbp:significance involved in digestion
involved in Alzheimer's disease
target for HIV drugs
gptkbp:structure two aspartate residues at the active site
gptkbp:subcellularLocation gptkb:lysosome
stomach
extracellular space
gptkbp:substrate gptkb:broadcaster
gptkbp:bfsParent gptkb:Napsin_A
gptkbp:bfsLayer 5