Statements (29)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:enzyme
|
gptkbp:activeSiteResidue |
aspartic acid residues
|
gptkbp:catalyzes |
hydrolysis of peptide bonds
|
gptkbp:compatibleWith |
metal ions for activity
|
gptkbp:enzymeCommissionNumber |
EC 3.4.23
|
gptkbp:example |
gptkb:renin
pepsin cathepsin D HIV-1 protease |
gptkbp:foundIn |
gptkb:Bacteria
animals fungi plants |
https://www.w3.org/2000/01/rdf-schema#label |
aspartic protease
|
gptkbp:inhibitedBy |
pepstatin
|
gptkbp:mechanismOfAction |
general acid-base catalysis
|
gptkbp:molecular_weight_range |
30-50 kDa
|
gptkbp:optimum_pH |
acidic
|
gptkbp:requires |
water for catalysis
|
gptkbp:significance |
involved in digestion
involved in Alzheimer's disease target for HIV drugs |
gptkbp:structure |
two aspartate residues at the active site
|
gptkbp:subcellularLocation |
gptkb:lysosome
stomach extracellular space |
gptkbp:substrate |
gptkb:broadcaster
|
gptkbp:bfsParent |
gptkb:Napsin_A
|
gptkbp:bfsLayer |
5
|