|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:serine/threonine_kinase_11
|
|
gptkbp:biologicalProcess
|
kinase activity
|
|
gptkbp:discoveredBy
|
Marx et al.
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:encodedBy
|
gptkb:STK11_gene
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:formsComplexWith
|
MO25
STRAD
|
|
gptkbp:function
|
tumor suppressor
regulation of cell cycle
regulation of metabolism
regulation of cell polarity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LKB1 protein
|
|
gptkbp:inhibitedBy
|
loss of STRAD or MO25
mutations in STK11
|
|
gptkbp:length
|
433 amino acids
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.3
|
|
gptkbp:molecularWeight
|
48 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Peutz-Jeghers_syndrome
|
|
gptkbp:orthologInMouse
|
gptkb:Stk11
|
|
gptkbp:overexpressedIn
|
gptkb:skeletal_muscle
gptkb:testis
liver
|
|
gptkbp:PDB
|
1O6L
|
|
gptkbp:phosphorylates
|
gptkb:AMPK
BRSK family kinases
MARK family kinases
SIK family kinases
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
gptkb:mTOR_signaling_pathway
gptkb:Wnt_signaling_pathway
apoptosis
cell proliferation
cell polarity
cellular energy homeostasis
|
|
gptkbp:requires
|
embryonic development
liver metabolism
hematopoietic stem cell maintenance
neuronal polarization
|
|
gptkbp:UniProtID
|
Q15831
|
|
gptkbp:bfsParent
|
gptkb:STK11
|
|
gptkbp:bfsLayer
|
7
|