SRF (serum response factor)

URI: https://gptkb.org/entity/SRF_(serum_response_factor)
GPTKB entity
Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:protein
transcription factor
gptkbp:alias gptkb:SRF
gptkb:Serum_response_factor
MADS box transcription enhancer factor 2
gptkbp:alternativeSplicing yes
gptkbp:binds gptkb:serum_response_element_(SRE)
gptkbp:discoveredBy gptkb:Richard_Treisman
gptkbp:discoveredIn 1986
gptkbp:domain gptkb:MADS-box
gptkbp:encodedBy gptkb:SRF_gene
gptkbp:Entrez_Gene_ID 6722
gptkbp:expressedIn gptkb:skeletal_muscle
heart
neurons
smooth muscle
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulation of gene expression
regulation of immediate-early genes
regulation of muscle-specific genes
https://www.w3.org/2000/01/rdf-schema#label SRF (serum response factor)
gptkbp:interactsWith gptkb:ELK1
gptkb:MRTF-A
gptkb:MRTF-B
TCF family proteins
gptkbp:length 508 amino acids
gptkbp:locatedOnChromosome gptkb:chromosome_6p21.1
gptkbp:molecularWeight 51 kDa
gptkbp:OMIM 600589
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
gptkbp:PDB 1HBX
gptkbp:phosphorylates gptkb:MAPK
gptkb:ERK
gptkbp:regulates gptkb:c-fos_gene
cell differentiation
wound healing
angiogenesis
cell growth
cell migration
muscle development
myogenesis
cellular proliferation
actin cytoskeleton genes
cytoskeletal gene expression
neuronal growth
immediate-early response genes
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:UniProtID P11831
gptkbp:bfsParent gptkb:ELK1
gptkb:Elk-1
gptkbp:bfsLayer 7