Extracellular superoxide dismutase [Cu-Zn]

URI: https://gptkb.org/entity/Extracellular_superoxide_dismutase_[Cu-Zn]
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:SOD3
gptkb:EC-SOD
gptkbp:biologicalProcess response to oxidative stress
superoxide dismutase activity
gptkbp:catalyzes dismutation of superoxide radical (O2-) to oxygen and hydrogen peroxide
gptkbp:cellularComponent extracellular region
gptkbp:cofactor copper
zinc
gptkbp:discoveredBy gptkb:Marklund_SL
gptkbp:discoveredIn 1982
gptkbp:EC_number 1.15.1.1
gptkbp:foundIn gptkb:human
mammals
gptkbp:function antioxidant defense
gptkbp:gene gptkb:SOD3
https://www.w3.org/2000/01/rdf-schema#label Extracellular superoxide dismutase [Cu-Zn]
gptkbp:locatedOnChromosome human chromosome 4p15.3-p15.1
gptkbp:location extracellular space
gptkbp:molecularWeight ~30 kDa (monomer)
gptkbp:mutationAssociatedWith gptkb:amyotrophic_lateral_sclerosis_(ALS)
asthma
gptkbp:PDB 1SXU
gptkbp:role cardiovascular health
lung function
protection against oxidative stress
gptkbp:secretes endothelial cells
fibroblasts
gptkbp:structure tetramer
gptkbp:UniProtID P08294
gptkbp:bfsParent gptkb:SOD3
gptkbp:bfsLayer 7