|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alias
|
gptkb:SOD3
gptkb:extracellular_SOD
Cu-Zn superoxide dismutase 3
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
gptkb:pneumonia
oxidative stress
|
|
gptkbp:binds
|
gptkb:heparin
extracellular matrix
|
|
gptkbp:cofactor
|
copper
zinc
|
|
gptkbp:discoveredBy
|
gptkb:Marklund_SL
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:EC_number
|
1.15.1.1
|
|
gptkbp:Entrez_Gene_ID
|
6649 (human)
|
|
gptkbp:family
|
gptkb:superoxide_dismutase_family
|
|
gptkbp:fullName
|
Extracellular superoxide dismutase
|
|
gptkbp:function
|
catalyzes the dismutation of superoxide radicals
|
|
gptkbp:gene
|
gptkb:SOD3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EC-SOD
|
|
gptkbp:inhibitedBy
|
gptkb:diethyldithiocarbamate
hydrogen peroxide
cyanide
|
|
gptkbp:locatedOnChromosome
|
4p15.3-p15.1 (human)
|
|
gptkbp:location
|
extracellular space
|
|
gptkbp:molecularWeight
|
135 kDa (tetramer)
|
|
gptkbp:OMIM
|
185490
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:PDB
|
gptkb:1PU0
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic processing
|
|
gptkbp:product
|
hydrogen peroxide (H2O2)
oxygen (O2)
|
|
gptkbp:secretionSignal
|
present
|
|
gptkbp:significance
|
biomarker for oxidative stress
therapeutic target for cardiovascular disease
|
|
gptkbp:structure
|
homotetramer
|
|
gptkbp:substrate
|
superoxide anion (O2−)
|
|
gptkbp:tissue_specificity
|
gptkb:cancer
gptkb:skin
gptkb:kidney
gptkb:placenta
brain
heart
liver
adipose tissue
pancreas
blood vessels
|
|
gptkbp:UniProtID
|
P08294 (human)
|
|
gptkbp:bfsParent
|
gptkb:SOD3
gptkb:extracellular_SOD
|
|
gptkbp:bfsLayer
|
7
|