|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:DPC4
gptkb:Mothers_against_decapentaplegic_homolog_4
gptkb:SMAD4
|
|
gptkbp:discoveredBy
|
gptkb:Bert_Vogelstein
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:domain
|
MH1 domain
MH2 domain
|
|
gptkbp:encodedBy
|
gptkb:SMAD4_gene
|
|
gptkbp:Entrez_Gene_ID
|
4089
ENSG00000141646
|
|
gptkbp:formsComplexWith
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:SMAD1
gptkb:SMAD5
gptkb:SMAD8
|
|
gptkbp:function
|
signal transduction
transcription factor
|
|
gptkbp:HGNC_ID
|
6770
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SMAD family member 4
|
|
gptkbp:interactsWith
|
gptkb:TGF-beta_receptor
co-SMADs
SMAD binding elements (SBE) in DNA
|
|
gptkbp:involvedIn
|
gptkb:BMP_signaling_pathway
gptkb:TGF-beta_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:18q21.2
gptkb:chromosome_18
|
|
gptkbp:molecularWeight
|
60 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:juvenile_polyposis_syndrome
gptkb:hereditary_hemorrhagic_telangiectasia
colorectal cancer
pancreatic cancer
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:1U7V
|
|
gptkbp:phosphorylates
|
Serine 465
Serine 467
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
embryonic development
gene expression
immune response
tumor suppression
fibrosis
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
gptkb:Q13485
|
|
gptkbp:bfsParent
|
gptkb:Mothers_against_decapentaplegic_homolog_4
|
|
gptkbp:bfsLayer
|
7
|