|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:SMAD3
gptkb:Mothers_against_decapentaplegic_homolog_3
|
|
gptkbp:associatedWith
|
gptkb:Loeys-Dietz_syndrome
colorectal cancer
fibrosis
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:domain
|
MH1 domain
MH2 domain
|
|
gptkbp:encodedBy
|
gptkb:SMAD3_gene
|
|
gptkbp:Entrez_Gene_ID
|
4088
ENSG00000166949
|
|
gptkbp:expressedIn
|
many human tissues
|
|
gptkbp:formsComplexWith
|
gptkb:SMAD4
|
|
gptkbp:function
|
signal transduction
transcription factor
|
|
gptkbp:HGNC_ID
|
6769
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SMAD family member 3
|
|
gptkbp:inhibitedBy
|
gptkb:SMAD7
|
|
gptkbp:interactsWith
|
gptkb:SMAD2
gptkb:CREBBP
gptkb:EP300
gptkb:TGFBR1
gptkb:SMAD4
|
|
gptkbp:involvedIn
|
gptkb:TGF-beta_signaling_pathway
apoptosis
cell differentiation
cell proliferation
immune response
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15
15q22.33
|
|
gptkbp:memberOf
|
SMAD protein family
|
|
gptkbp:MIMNumber
|
603109
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
|
|
gptkbp:phosphorylates
|
TGF-beta receptor kinases
|
|
gptkbp:regulates
|
gene expression
TGF-beta target genes
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
Q15796
|
|
gptkbp:bfsParent
|
gptkb:SMAD3
|
|
gptkbp:bfsLayer
|
7
|