|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:5-HTTLPR
gptkb:5HTT
gptkb:SERT
gptkb:HTT
|
|
gptkbp:alternativeName
|
gptkb:5-HTT
gptkb:solute_carrier_family_6_member_4
gptkb:serotonin_transporter
|
|
gptkbp:associatedWith
|
gptkb:depression
gptkb:autism_spectrum_disorder
gptkb:obsessive-compulsive_disorder
anxiety
irritable bowel syndrome
stress response
alcohol dependence
response to antidepressants
serotonin transporter-linked polymorphic region (5-HTTLPR)
|
|
gptkbp:biologicalProcess
|
neurotransmitter transport
serotonin uptake
serotonin:sodium symporter activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Kuhar_et_al.
|
|
gptkbp:encodes
|
gptkb:serotonin_transporter
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000108576
6532
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:placenta
brain
gastrointestinal tract
|
|
gptkbp:firstDescribed
|
1993
|
|
gptkbp:function
|
serotonin reuptake
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
gptkb:5-HTTLPR
rs25531
|
|
gptkbp:hasTranscriptVariant
|
gptkb:NM_001045
NM_001282543
NM_001282545
|
|
gptkbp:HGNC_ID
|
11050
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SLC6A4 (human)
|
|
gptkbp:length
|
630 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q11.2
|
|
gptkbp:OMIM
|
182138
|
|
gptkbp:orthologInMouse
|
gptkb:Slc6a4
|
|
gptkbp:product
|
gptkb:SERT
|
|
gptkbp:proteinFamily
|
gptkb:solute_carrier_family_6
|
|
gptkbp:target
|
gptkb:tricyclic_antidepressants
gptkb:selective_serotonin_reuptake_inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P31645
|
|
gptkbp:bfsParent
|
gptkb:Slc6a4
|
|
gptkbp:bfsLayer
|
7
|