|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:ESET
gptkb:KMT1E
|
|
gptkbp:amendedBy
|
gptkb:histone_H3_lysine_9_(H3K9)
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodevelopmental disorders
|
|
gptkbp:component
|
nuclear chromatin
|
|
gptkbp:discoveredBy
|
Rea S et al.
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:domain
|
gptkb:post-SET_domain
SET domain
bifurcated SET domain
pre-SET domain
|
|
gptkbp:encodes
|
gptkb:SET_domain_bifurcated_1_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000143374
9869
|
|
gptkbp:expressedIn
|
gptkb:nucleus
gptkb:testis
brain
liver
|
|
gptkbp:function
|
histone methyltransferase activity
histone methyltransferase
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
gene silencing
chromatin organization
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SETDB1
|
|
gptkbp:inhibitedBy
|
gptkb:BIX-01294
gptkb:UNC0638
|
|
gptkbp:interactsWith
|
gptkb:DNMT3A
gptkb:DNMT3B
gptkb:MBD1
gptkb:TRIM28
|
|
gptkbp:involvedIn
|
epigenetic gene silencing
|
|
gptkbp:length
|
1291
|
|
gptkbp:locatedOnChromosome
|
1q21.3
|
|
gptkbp:molecularWeight
|
143 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
melanoma
|
|
gptkbp:OMIM
|
604396
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:phosphorylates
|
gptkb:Serine_1006
Serine 1061
|
|
gptkbp:regulates
|
transcriptional repression
heterochromatin formation
retrotransposon silencing
|
|
gptkbp:UniProtID
|
gptkb:Q15047
|
|
gptkbp:bfsParent
|
gptkb:ERH
|
|
gptkbp:bfsLayer
|
6
|