Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:associatedWith |
gptkb:RhoA
gptkb:Cdc42 |
| gptkbp:biologicalProcess |
GTPase activity
|
| gptkbp:discoveredBy |
1990s
|
| gptkbp:family |
gptkb:Rho_family_of_GTPases
|
| gptkbp:form |
GTP-bound
|
| gptkbp:function |
gene expression
cell cycle progression cell growth cell migration regulation of actin cytoskeleton |
| gptkbp:gene |
gptkb:RAC1
RAC2 RAC3 |
| https://www.w3.org/2000/01/rdf-schema#label |
Rac protein
|
| gptkbp:inactive_form |
GDP-bound
|
| gptkbp:interactsWith |
gptkb:PAK1
gptkb:Tiam1 gptkb:WAVE_complex gptkb:DOCK180 gptkb:IQGAP1 |
| gptkbp:involves |
wound healing
angiogenesis cancer progression inflammation immune response neuronal development cellular transformation cellular signaling |
| gptkbp:location |
gptkb:cytoplasm
gptkb:plasma_membrane |
| gptkbp:member |
small GTP-binding proteins
|
| gptkbp:organism |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:PDB |
gptkb:1MH1
|
| gptkbp:postTranslationalModification |
prenylation
phosphorylation |
| gptkbp:regulates |
phagocytosis
cell polarity cell adhesion lamellipodia formation reactive oxygen species production NADPH oxidase activity by GAPs (GTPase-activating proteins) by GEFs (guanine nucleotide exchange factors) by GDIs (guanine nucleotide dissociation inhibitors) |
| gptkbp:structure |
GTPase domain
|
| gptkbp:UniProtID |
P63000 (RAC1)
|
| gptkbp:bfsParent |
gptkb:Rho_protein
|
| gptkbp:bfsLayer |
6
|