|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:associatedWith
|
gptkb:cancer
melanoma
schizophrenia
neurodevelopmental disorders
mental retardation
|
|
gptkbp:biologicalProcess
|
GTP binding
GTPase activity
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.6.5.2
|
|
gptkbp:function
|
cell proliferation
cell cycle progression
cell migration
gene expression regulation
cell adhesion
regulation of actin cytoskeleton
lamellipodia formation
NADPH oxidase activation
|
|
gptkbp:GO_term
|
GO:0007264
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Rac1 GTPase
|
|
gptkbp:inhibitedBy
|
gptkb:GDP_dissociation_inhibitors_(GDIs)
GTPase-activating proteins (GAPs)
|
|
gptkbp:interactsWith
|
gptkb:PAK1
gptkb:Tiam1
gptkb:WAVE_complex
gptkb:RhoGDI
gptkb:DOCK180
gptkb:IQGAP1
gptkb:NADPH_oxidase_complex
|
|
gptkbp:length
|
192
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p22
|
|
gptkbp:memberOf
|
gptkb:small_GTPase_superfamily
Rho family GTPases
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
constitutive activation
P29S
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Drosophila melanogaster Rac1
Mus musculus Rac1
|
|
gptkbp:PDB
|
gptkb:1MH1
|
|
gptkbp:postTranslationalModification
|
prenylation
phosphorylation
ubiquitination
|
|
gptkbp:product
|
gptkb:RAC1_gene
|
|
gptkbp:structure
|
monomeric
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P63000
|
|
gptkbp:bfsParent
|
gptkb:WAVE_complex
|
|
gptkbp:bfsLayer
|
8
|