Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:Ras-related_C3_botulinum_toxin_substrate_1
TC25 MGC111543 |
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:cancer
developmental disorders |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:encodes |
Rac1 protein
|
| gptkbp:Entrez_Gene_ID |
gptkb:ENSG00000136238
5879 |
| gptkbp:expressedIn |
many tissues
|
| gptkbp:function |
cell cycle progression
cell migration regulation of gene expression regulation of cell growth regulation of cytoskeleton organization |
| gptkbp:HGNC_ID |
9801
|
| https://www.w3.org/2000/01/rdf-schema#label |
RAC1 gene
|
| gptkbp:involvedIn |
gptkb:MAPK_signaling_pathway
gptkb:Wnt_signaling_pathway signal transduction cellular senescence angiogenesis immune response phagocytosis cellular response to growth factor stimulus axon guidance platelet activation neural crest cell migration |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_7
7p22.1 |
| gptkbp:mutationAssociatedWith |
can cause intellectual disability
can cause cancer progression can cause developmental delay |
| gptkbp:OMIM |
602048
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
gptkb:Rac1
|
| gptkbp:proteinFamily |
gptkb:Rho_GTPase_family
|
| gptkbp:regulates |
cell proliferation
cell survival cell polarity actin cytoskeleton cell adhesion cell motility reactive oxygen species production NADPH oxidase activity |
| gptkbp:UniProtID |
gptkb:P63000
|
| gptkbp:bfsParent |
gptkb:RAC_(Ras-related_C3_botulinum_toxin_substrate)
gptkb:Rac1 |
| gptkbp:bfsLayer |
7
|