|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:RhoA_GTPase
|
|
gptkbp:alternativeName
|
ROKβ
p160ROCK
rho-kinase 1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
neurodegenerative disease
fibrosis
|
|
gptkbp:discoveredBy
|
Matsui et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:domain
|
gptkb:PH_domain
kinase domain
cysteine-rich domain
coiled-coil domain
|
|
gptkbp:encodedBy
|
gptkb:ROCK1_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000143324
|
|
gptkbp:fullName
|
Rho-associated protein kinase 1
|
|
gptkbp:function
|
apoptosis
cell migration
serine/threonine kinase activity
regulation of actin cytoskeleton
cell contraction
|
|
gptkbp:gene
|
gptkb:ROCK1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ROCK1
|
|
gptkbp:inhibitedBy
|
gptkb:Y-27632
gptkb:fasudil
|
|
gptkbp:locatedOnChromosome
|
chromosome 18q11.1
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~158 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
2ETR
|
|
gptkbp:phosphorylates
|
gptkb:LIM_kinase
myosin light chain
|
|
gptkbp:RefSeq
|
NM_005406
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
gene expression
cell shape
cell polarity
cell adhesion
cytokinesis
focal adhesion formation
smooth muscle contraction
stress fiber formation
neurite retraction
|
|
gptkbp:relatedTo
|
gptkb:ROCK2
|
|
gptkbp:UniProtID
|
Q13464
|
|
gptkbp:bfsParent
|
gptkb:PPP1R12A
gptkb:RhoE
gptkb:ROCK_(Rho-associated_kinase)
gptkb:Ras_homolog_family_member_A
|
|
gptkbp:bfsLayer
|
7
|