|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
ROKβ
p160ROCK
|
|
gptkbp:associatedWith
|
gptkb:cancer
cardiovascular diseases
|
|
gptkbp:clinicalTrialPhase
|
gptkb:cancer
gptkb:cardiovascular_disease
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
Rho-associated protein kinase 1
|
|
gptkbp:Entrez_Gene_ID
|
6093
ENSG00000143324
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
apoptosis
cell migration
regulation of actin cytoskeleton
cell contraction
|
|
gptkbp:HGNC_ID
|
10251
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ROCK1 gene
|
|
gptkbp:inhibitedBy
|
gptkb:Y-27632
gptkb:fasudil
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_18
|
|
gptkbp:mutationAssociatedWith
|
metastasis
tumor progression
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Rock1
|
|
gptkbp:pathway
|
actin cytoskeleton regulation
Rho signaling pathway
|
|
gptkbp:phosphorylates
|
gptkb:LIM_kinase
myosin light chain
ERM proteins
|
|
gptkbp:proteinFamily
|
serine/threonine kinase
|
|
gptkbp:regulates
|
cell shape
myosin light chain phosphorylation
smooth muscle contraction
activated by RhoA GTPase
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q13464
|
|
gptkbp:bfsParent
|
gptkb:ROCK_(Rho-associated_kinase)
|
|
gptkbp:bfsLayer
|
7
|