|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
ROKα
Rho-kinase 2
Rho-associated, coiled-coil containing protein kinase II
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
fibrosis
|
|
gptkbp:biologicalProcess
|
protein serine/threonine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
Masaki et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
Rho-associated protein kinase 2
|
|
gptkbp:Entrez_Gene_ID
|
9475
ENSG00000134318
|
|
gptkbp:fullName
|
Rho-associated, coiled-coil containing protein kinase 2
|
|
gptkbp:function
|
apoptosis
cell proliferation
cell migration
regulation of actin cytoskeleton
smooth muscle contraction
|
|
gptkbp:HGNC_ID
|
10252
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ROCK2
|
|
gptkbp:inhibitedBy
|
gptkb:Y-27632
gptkb:fasudil
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Rock2
|
|
gptkbp:product
|
ROCK2 protein
|
|
gptkbp:regulates
|
myosin light chain phosphorylation
actin-myosin contraction
|
|
gptkbp:UniProtID
|
O75116
|
|
gptkbp:bfsParent
|
gptkb:PPP1R12A
gptkb:ROCK_(Rho-associated_kinase)
gptkb:Ras_homolog_family_member_A
|
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gptkbp:bfsLayer
|
7
|